PTPRR

Across TCGA cell cohorts, PTPRR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,848 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PTPRR-associated GO terms across cancer lineages are Negative regulation of immune response, Plasma membrane organization, and Negative regulation of calcineurin-mediated signaling. Each is linked with PTPRR in more than 11 cancer types. Because this analysis shows association rather than direction, both PTPRR-to-partner and partner-to-PTPRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of immune response grouped by PTPRR-low versus PTPRR-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRR→partner) and Y-score (partner→PTPRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of immune response →	+0.108	+1.080	<.001	<.001	3	12
LIVER	Plasma membrane organization →	+0.112	+1.553	.003	.003	3	12
LIVER	Negative regulation of calcineurin-mediated signaling →	+0.226	+1.336	<.001	.001	3	11
LIVER	Negative regulation of calcineurin-NFAT signaling cascade →	+0.226	+1.336	<.001	.001	3	11
BREAST	Positive regulation of cellular response to hypoxia →	-0.953	-1.055	<.001	.003	3	10
OVARY	Sterol catabolic process →	-0.287	-1.981	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,848 associations by consensus.

Negative regulation of immune response by PTPRR expression — BREAST

Explore this box plot interactively →