PTPRR

Across TCGA cell cohorts, PTPRR mutation is significantly associated with the RNA expression of many other genes, with 168 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRR-associated genes across cancer lineages are NKX2-6, C3orf85, and TLE7. Each is linked with PTPRR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRR-to-partner and partner-to-PTPRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by PTPRR-low versus PTPRR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRR→partner) and Y-score (partner→PTPRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	C3orf85 →	+0.059	+5.539	<.001	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
CNS	MCHR2 →	+0.083	+3.930	<.001	.005	3	1
CNS	DEFB133 →	+0.028	+4.772	<.001	.002	3	1
LARGE_INTESTINE	JOSD1 →	+0.553	+3.364	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 168 associations by consensus.

NKX2-6 by PTPRR expression — BLOOD_Leukemia

Explore this box plot interactively →