PTPRQ

Across TCGA patient cohorts, PTPRQ mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRQ-associated genes across cancer lineages are GAPDH, p21, and TFRC. Each is linked with PTPRQ in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRQ-to-partner and partner-to-PTPRQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PTPRQ-low versus PTPRQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRQ→partner) and Y-score (partner→PTPRQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.344	+1.502	.027	.027	3	2
UCEC	p21 →	+0.128	+1.765	.022	.013	3	2
UCEC	TFRC →	+0.450	+2.222	.003	.009	3	2
UCEC	TIGAR →	+0.100	+1.736	.024	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.635	+1.682	<.001	.006	3	2
UCEC	Chk2_pT68 →	-0.161	-1.864	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

GAPDH by PTPRQ expression — UCEC

Explore this box plot interactively →