PTPRQ

Across TCGA cell cohorts, PTPRQ RNA expression is significantly associated with the go_rna of many other GO terms, with 887 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PTPRQ-associated GO terms across cancer lineages are Positive regulation of DNA-templated transcription, elongation, Regulation of transcription initiation by RNA polymerase II, and Short-chain fatty acid transport. Each is linked with PTPRQ in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRQ-to-partner and partner-to-PTPRQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-templated transcription, elongation grouped by PTPRQ-low versus PTPRQ-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRQ→partner) and Y-score (partner→PTPRQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA-templated transcription, elongation →	+0.079	+0.565	<.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.052	+0.630	<.001	.006	3	5
LUNG_SCLC	Short-chain fatty acid transport →	+0.941	+0.696	.002	.001	3	5
LUNG_NSCLC_LUSC	Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.052	+0.297	.004	.008	3	5
SKIN	Response to interleukin-12 →	-0.162	-0.075	<.001	<.001	3	5
SOFT_TISSUE	Steroid catabolic process →	-0.221	-0.823	<.001	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 887 associations by consensus.

Positive regulation of DNA-templated transcription, elongation by PTPRQ expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →