PTPRQ

Across TCGA cell cohorts, PTPRQ mutation is significantly associated with the RNA expression of many other genes, with 535 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRQ-associated genes across cancer lineages are SSX7, CIB4, and UHRF1BP1L. Each is linked with PTPRQ in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRQ-to-partner and partner-to-PTPRQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX7 grouped by PTPRQ-low versus PTPRQ-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRQ→partner) and Y-score (partner→PTPRQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SSX7 →	+0.038	+3.977	.003	.006	3	4
BREAST	CIB4 →	+0.607	+3.602	<.001	.005	3	2
LARGE_INTESTINE	UHRF1BP1L →	+0.572	+2.502	.001	.005	3	2
LARGE_INTESTINE	SENP6 →	+0.544	+2.502	.004	.005	3	2
LARGE_INTESTINE	C12orf65 →	+0.450	+2.502	.001	.005	3	2
LARGE_INTESTINE	BTF3L4 →	+0.647	+3.321	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 535 associations by consensus.

SSX7 by PTPRQ expression — LIVER

Explore this box plot interactively →