PTPRO

Across TCGA patient cohorts, PTPRO mutation is significantly associated with the RNA expression of many other genes, with 6,662 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRO-associated genes across cancer lineages are TIMM17A, SNX24, and FH. Each is linked with PTPRO in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRO-to-partner and partner-to-PTPRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM17A grouped by PTPRO-low versus PTPRO-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRO→partner) and Y-score (partner→PTPRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TIMM17A →	+0.480	+3.482	<.001	.002	3	4
SKCM	SNX24 →	+0.660	+2.761	<.001	<.001	3	4
LUAD	FH →	+0.594	+3.602	<.001	.001	3	4
UCEC	NEK2 →	+0.486	+1.668	.003	.003	3	4
UCEC	TACC3 →	+0.637	+2.000	<.001	<.001	3	4
UCEC	MRPL17 →	+0.257	+1.673	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,662 associations by consensus.

TIMM17A by PTPRO expression — LUAD

Explore this box plot interactively →