PTPRO

Across TCGA pan-cancer cohorts, PTPRO RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PTPRO’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PTPRO RNA is repressed in tumor relative to normal tissue. In most cancer types PTPRO is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

LUAD, HNSC, and THCA are the cancer types where PTPRO tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRO RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.544	<.001	11	view →
HNSC	All	III,IV	+0.544	<.001	11	view →
THCA	All	III,IV	+0.506	<.001	11	view →
KIRC	Male	All	−1.582	<.001	10	view →
KIRP	Female	II,III,IV	−3.014	<.001	9	view →
LUSC	Female	II,III,IV	−1.787	<.001	8	view →
KICH	Female	All	−3.233	<.001	7	view →
COAD	All	All	+1.157	.001	7	view →
STAD	All	II,III,IV	+0.668	<.001	7	view →
BRCA	All	III,IV	+0.660	<.001	6	view →
CHOL	All	All	+0.950	<.001	5	view →
READ	Male	All	−1.069	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PTPRO–LUAD

Open the LUAD breakdown →