PTPRO

Across TCGA patient cohorts, PTPRO mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRO-associated genes across cancer lineages are PCNA, PKC-b-II_pS660, and 4E-BP1. Each is linked with PTPRO in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRO-to-partner and partner-to-PTPRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PTPRO-low versus PTPRO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRO→partner) and Y-score (partner→PTPRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.182	+2.044	.002	<.001	3	4
UCEC	PKC-b-II_pS660 →	-0.176	-0.947	.023	.047	3	4
UCEC	4E-BP1 →	+0.328	+3.321	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.586	+1.632	<.001	<.001	3	3
UCEC	Akt_pT308 →	+0.351	+0.947	.047	.047	3	3
UCEC	PKC-delta_pS664 →	-0.075	-1.700	.025	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

PCNA by PTPRO expression — UCEC

Explore this box plot interactively →