PTPRO

Across TCGA cell cohorts, PTPRO RNA expression is significantly associated with the go_rna of many other GO terms, with 2,451 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTPRO-associated GO terms across cancer lineages are Regulation of retinal ganglion cell axon guidance, Regulation of tumor necrosis factor (ligand) superfamily member 11 production, and Lipoxin A4 biosynthetic process. Each is linked with PTPRO in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPRO-to-partner and partner-to-PTPRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of retinal ganglion cell axon guidance grouped by PTPRO-low versus PTPRO-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRO→partner) and Y-score (partner→PTPRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of retinal ganglion cell axon guidance →	+1.346	+3.025	<.001	<.001	3	7
LARGE_INTESTINE	Regulation of tumor necrosis factor (ligand) superfamily member 11 production →	-0.756	-1.794	.002	.001	3	6
CNS	Lipoxin A4 biosynthetic process →	-0.085	-0.665	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of TORC1 signaling →	+0.055	+0.251	<.001	.001	3	5
LUNG_SCLC	Carbohydrate transport →	-0.043	-1.245	.009	.004	2	6
BLOOD_Leukemia	Nail development →	-0.524	-0.412	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,451 associations by consensus.

Regulation of retinal ganglion cell axon guidance by PTPRO expression — LARGE_INTESTINE

Explore this box plot interactively →