PTPRO

Across TCGA cell cohorts, PTPRO mutation is significantly associated with the RNA expression of many other genes, with 486 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRO-associated genes across cancer lineages are CA1, MYL6B, and SLCO1C1. Each is linked with PTPRO in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRO-to-partner and partner-to-PTPRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CA1 grouped by PTPRO-low versus PTPRO-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRO→partner) and Y-score (partner→PTPRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CA1 →	+0.159	+2.339	.001	.003	3	2
SKIN	MYL6B →	-0.500	-3.169	.006	.009	3	2
BLOOD_Leukemia	SLCO1C1 →	+0.042	+2.799	<.001	.005	3	2
BLOOD_Leukemia	KRTAP4-11 →	+0.013	+3.539	<.001	.002	3	2
LARGE_INTESTINE	GPR63 →	+0.885	+3.212	<.001	.006	3	2
LARGE_INTESTINE	SERP1 →	+0.504	+3.299	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 486 associations by consensus.

CA1 by PTPRO expression — SKIN

Explore this box plot interactively →