PTPRN2

Across TCGA cell cohorts, PTPRN2 mutation is significantly associated with the RNA expression of many other genes, with 731 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTPRN2-associated genes across cancer lineages are FABP12, NUP88, and CD72. Each is linked with PTPRN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRN2-to-partner and partner-to-PTPRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FABP12 grouped by PTPRN2-low versus PTPRN2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRN2→partner) and Y-score (partner→PTPRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FABP12 →	+0.189	+4.981	<.001	.008	3	2
LARGE_INTESTINE	NUP88 →	+0.530	+2.667	<.001	<.001	3	2
LARGE_INTESTINE	CD72 →	+0.424	+2.130	<.001	<.001	3	2
LARGE_INTESTINE	FAM149B1 →	+0.354	+1.893	.001	.001	3	2
LARGE_INTESTINE	GAL3ST2 →	+1.186	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	GKAP1 →	+0.645	+2.130	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 731 associations by consensus.

FABP12 by PTPRN2 expression — CNS

Explore this box plot interactively →