PTPRN2

Across TCGA pan-cancer cohorts, PTPRN2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PTPRN2 data layer compared with 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PTPRN2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PTPRN2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and UCEC are the cancer types where PTPRN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.623	0.456	<.001	95	view →
KIRC	DFS	Tertile	All	0.730	0.537	<.001	85	view →
UCEC	DFS	Median	All	0.933	0.860	<.001	44	view →
GBM	OS	Tertile	All	0.318	0.528	<.001	39	view →
LAML	DFS	Median	All	0.345	0.584	.002	38	view →
ESCA	DFS	Quartile	All	0.205	1.000	.001	30	view →
SKCM	OS	Median	III,IV	0.918	0.757	.009	26	view →
UVM	DFS	Quartile	All	1.000	0.602	.005	25	view →
COAD	DFS	Tertile	III,IV	0.627	0.272	.017	22	view →
ACC	DFS	Tertile	All	0.172	0.538	.022	19	view →
PRAD	DFS	Median	All	0.932	0.837	<.001	18	view →
LUAD	DFS	Tertile	III,IV	0.320	0.657	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PTPRN2–HNSC (DFS)

Open the HNSC breakdown →