PTPRN2

Across TCGA cell cohorts, PTPRN2 mutation is significantly associated with the mutation status of many other genes, with 4,937 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRN2-associated genes across cancer lineages are FLNA, RP1, and CWC22. Each is linked with PTPRN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRN2-to-partner and partner-to-PTPRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLNA grouped by PTPRN2-low versus PTPRN2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRN2→partner) and Y-score (partner→PTPRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FLNA →	+5.115	+5.115	.005	.005	1	6
LARGE_INTESTINE	RP1 →	+1.828	+1.906	<.001	<.001	1	6
OVARY	CWC22 →	+3.977	+4.930	.001	.001	1	6
CNS	CECR2 →	+4.044	+5.000	.008	.008	1	6
OVARY	XDH →	+4.562	+5.217	<.001	<.001	1	6
OVARY	PRKDC →	+3.562	+4.684	.002	.002	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,937 associations by consensus.

FLNA by PTPRN2 expression — PANCREAS

Explore this box plot interactively →