PTPRN

Across TCGA cell cohorts, PTPRN mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PTPRN-associated genes across cancer lineages are ZAN, C1orf87, and DYNAP. Each is linked with PTPRN in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRN-to-partner and partner-to-PTPRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by PTPRN-low versus PTPRN-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRN→partner) and Y-score (partner→PTPRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZAN →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	C1orf87 →	+0.055	+5.000	<.001	.006	3	1
BLOOD_Lymphoma	DYNAP →	+0.071	+4.867	.002	.009	3	1
LARGE_INTESTINE	PROP1 →	+0.017	+2.791	.003	.005	3	1
LARGE_INTESTINE	DCDC2C →	+0.057	+2.688	<.001	.008	3	1
LARGE_INTESTINE	TBC1D3 →	+0.085	+3.425	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ZAN by PTPRN expression — PANCREAS

Explore this box plot interactively →