PTPRM

Across TCGA cell cohorts, PTPRM mutation is significantly associated with the RNA expression of many other genes, with 845 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRM-associated genes across cancer lineages are AP1AR, SPAG11A, and SPATA31D1. Each is linked with PTPRM in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPRM-to-partner and partner-to-PTPRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1AR grouped by PTPRM-low versus PTPRM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRM→partner) and Y-score (partner→PTPRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AP1AR →	+0.702	+2.222	<.001	.001	3	3
BONE	SPAG11A →	+0.120	+5.129	<.001	<.001	3	2
LUNG_SCLC	SPATA31D1 →	+0.506	+4.058	<.001	.007	3	2
BONE	OR52R1 →	+0.035	+4.169	<.001	.008	3	2
OESOPHAGUS	OR5B12 →	+0.017	+3.392	<.001	.007	3	2
URINARY_TRACT	PF4V1 →	+0.174	+3.459	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 845 associations by consensus.

AP1AR by PTPRM expression — LARGE_INTESTINE

Explore this box plot interactively →