PTPRH

Across TCGA patient cohorts, PTPRH mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRH-associated genes across cancer lineages are CDK1, 4E-BP1_pT70, and Cyclin-B1. Each is linked with PTPRH in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPRH-to-partner and partner-to-PTPRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by PTPRH-low versus PTPRH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRH→partner) and Y-score (partner→PTPRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDK1 →	+0.295	+2.815	.003	.036	3	5
LUAD	4E-BP1_pT70 →	+0.185	+3.000	.034	.035	3	3
UCEC	Cyclin-B1 →	+0.593	+2.321	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.274	-1.227	.038	.015	3	3
UCEC	TIGAR →	+0.129	+1.459	.004	.003	3	3
COAD	Chk1 →	+0.354	+2.815	.003	.036	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

CDK1 by PTPRH expression — COAD

Explore this box plot interactively →