PTPRH

Across TCGA cell cohorts, PTPRH mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PTPRH-associated genes across cancer lineages are KCNA5, PRAMEF5, and CPN2. Each is linked with PTPRH in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRH-to-partner and partner-to-PTPRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA5 grouped by PTPRH-low versus PTPRH-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRH→partner) and Y-score (partner→PTPRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KCNA5 →	+0.043	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	PRAMEF5 →	+0.106	+5.357	<.001	.003	3	2
BLOOD_Myeloma	CPN2 →	+0.007	+4.754	<.001	<.001	3	1
LUNG_SCLC	TNP1 →	+0.466	+5.169	<.001	<.001	3	1
LUNG_SCLC	OR2M7 →	+0.030	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

KCNA5 by PTPRH expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →