PTPRG-AS1

Across TCGA pan-cancer cohorts, PTPRG-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PTPRG-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher PTPRG-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTPRG-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

MESO, ESCA, and UCEC are the cancer types where PTPRG-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.255	0.461	.001	43	view →
ESCA	OS	Tertile	II,III,IV	0.395	0.720	<.001	41	view →
UCEC	DFS	Tertile	All	0.562	0.703	<.001	34	view →
SKCM	DFS	Tertile	II,III,IV	0.215	0.518	<.001	25	view →
HNSC	DFS	Tertile	IV	0.581	0.224	.001	24	view →
KIRC	DFS	Quartile	IV	0.208	0.528	.008	22	view →
SARC	OS	Tertile	All	0.425	0.799	<.001	22	view →
LUAD	DFS	Median	IV	0.741	0.260	.007	18	view →
UVM	OS	Median	III,IV	0.246	0.836	.003	14	view →
LAML	DFS	Quartile	All	0.569	0.293	.027	12	view →
READ	OS	Median	II,III,IV	0.767	0.491	.018	11	view →
ACC	OS	Median	IV	0.344	0.724	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PTPRG-AS1–MESO (DFS)

Open the MESO breakdown →