PTPRG-AS1

Across TCGA pan-cancer cohorts, PTPRG-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PTPRG-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PTPRG-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTPRG-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

LUAD, COAD, and KIRP are the cancer types where PTPRG-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRG-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+0.721	<.001	11	view →
COAD	All	II,III,IV	+0.166	<.001	10	view →
KIRP	All	All	+0.285	<.001	9	view →
BLCA	All	All	+0.477	.003	8	view →
LIHC	All	All	+0.101	<.001	8	view →
BRCA	All	II,III,IV	+0.420	<.001	6	view →
KIRC	All	All	−0.120	.005	5	view →
CHOL	All	II,III,IV	+0.794	<.001	4	view →
LUSC	Male	All	+0.386	<.001	4	view →
HNSC	All	All	+0.169	.018	4	view →
THCA	Male	IV	−0.280	.015	2	view →
KICH	Female	All	−0.237	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PTPRG-AS1–LUAD

Open the LUAD breakdown →