PTPRF

Across TCGA patient cohorts, PTPRF protein abundance is significantly associated with the RNA expression of many other genes, with 15,450 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PTPRF-associated genes across cancer lineages are GYPC, IFFO1, and FLI1. Each is linked with PTPRF in more than 7 cancer types. Because this analysis shows association rather than direction, both PTPRF-to-partner and partner-to-PTPRF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPRF versus GYPC in OV, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRF→partner) and Y-score (partner→PTPRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GYPC →	-0.876	-0.562	.004	<.001	3	8
OV	IFFO1 →	-0.866	-0.502	<.001	.001	3	7
HNSC	FLI1 →	-0.679	-0.625	<.001	<.001	3	7
OV	JAML →	-0.812	-0.436	<.001	<.001	3	7
HNSC	GIMAP8 →	-0.657	-0.558	<.001	<.001	3	7
HNSC	KLHL6 →	-0.967	-0.672	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,450 associations by consensus.

PTPRF vs GYPC — OV

Explore this scatter interactively →