PTPRF

Across TCGA pan-cancer cohorts, PTPRF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PTPRF’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTPRF RNA is repressed in tumor relative to normal tissue. In most cancer types PTPRF is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LUSC, and LIHC are the cancer types where PTPRF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.886	<.001	9	view →
LUSC	Female	All	+1.641	<.001	8	view →
LIHC	Female	All	+1.169	<.001	7	view →
BLCA	All	All	+0.856	.001	7	view →
HNSC	All	All	+0.823	<.001	7	view →
CHOL	All	All	+2.653	<.001	5	view →
STAD	All	II,III,IV	+1.091	.001	5	view →
KIRP	All	IV	+0.822	.027	5	view →
LUAD	All	All	+0.398	<.001	5	view →
KICH	All	All	−0.652	.006	4	view →
READ	All	II,III,IV	−0.945	.011	3	view →
THCA	All	All	+0.389	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PTPRF–COAD

Open the COAD breakdown →