PTPRF

Across TCGA patient cohorts, PTPRF mutation is significantly associated with the RNA expression of many other genes, with 6,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRF-associated genes across cancer lineages are SAPCD2, ZWILCH, and SPDL1. Each is linked with PTPRF in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPRF-to-partner and partner-to-PTPRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAPCD2 grouped by PTPRF-low versus PTPRF-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRF→partner) and Y-score (partner→PTPRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SAPCD2 →	+0.708	+3.380	.002	.004	3	5
UCEC	ZWILCH →	+0.478	+1.451	<.001	<.001	3	5
CESC	SPDL1 →	+0.489	+2.715	.003	.002	3	5
COAD	SLC17A5 →	+0.456	+2.375	.002	.003	3	5
LUAD	KIF11 →	+0.970	+3.471	.002	.002	3	5
LUAD	INSL4 →	+1.849	+2.878	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,149 associations by consensus.

SAPCD2 by PTPRF expression — CESC

Explore this box plot interactively →