PTPRF

Across TCGA patient cohorts, PTPRF mutation is significantly associated with the total protein of many other genes, with 85 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PTPRF-associated genes across cancer lineages are ATM, Chk2, and c-Kit. Each is linked with PTPRF in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPRF-to-partner and partner-to-PTPRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PTPRF-low versus PTPRF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRF→partner) and Y-score (partner→PTPRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.534	-1.765	<.001	<.001	3	5
LUAD	Chk2 →	+0.504	+3.169	<.001	.019	3	4
STAD	c-Kit →	-0.453	-3.321	.001	.009	3	4
UCEC	4E-BP1_pT37_T46 →	-0.243	-1.649	.017	.009	3	4
STAD	FoxM1 →	+0.346	+2.201	.003	.031	3	3
STAD	Ku80 →	+0.305	+3.169	.026	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

ATM by PTPRF expression — UCEC

Explore this box plot interactively →