PTPRF

Across TCGA cell cohorts, PTPRF mutation is significantly associated with the RNA expression of many other genes, with 481 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRF-associated genes across cancer lineages are SKA1, MS4A10, and ADAM7. Each is linked with PTPRF in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPRF-to-partner and partner-to-PTPRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by PTPRF-low versus PTPRF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRF→partner) and Y-score (partner→PTPRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SKA1 →	+0.817	+2.743	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	MS4A10 →	+0.008	+3.510	.003	.007	3	2
UPPER_AERODIGESTIVE_TRACT	ADAM7 →	+0.014	+3.917	<.001	.004	3	2
LUNG_NSCLC_LUAD	TEX13A →	+0.019	+4.019	<.001	<.001	3	2
LARGE_INTESTINE	MTHFD1 →	+0.569	+2.743	.001	.001	3	2
LARGE_INTESTINE	ZBED3 →	+0.896	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 481 associations by consensus.

SKA1 by PTPRF expression — LARGE_INTESTINE

Explore this box plot interactively →