PTPRC

Across TCGA cell cohorts, PTPRC mutation is significantly associated with the RNA expression of many other genes, with 631 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRC-associated genes across cancer lineages are AMER2, KHDC3L, and MPL. Each is linked with PTPRC in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRC-to-partner and partner-to-PTPRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMER2 grouped by PTPRC-low versus PTPRC-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRC→partner) and Y-score (partner→PTPRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AMER2 →	+0.010	+3.459	<.001	.004	3	2
LIVER	KHDC3L →	+0.042	+3.662	<.001	.005	3	2
LARGE_INTESTINE	MPL →	+0.103	+2.129	.002	.007	3	2
SKIN	PCBD2 →	+0.574	+3.131	.001	.008	3	2
SKIN	LIPK →	+0.031	+2.202	<.001	.006	3	2
SKIN	ZNF487 →	+0.559	+2.624	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 631 associations by consensus.

AMER2 by PTPRC expression — LIVER

Explore this box plot interactively →