PTPRB

Across TCGA pan-cancer cohorts, PTPRB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PTPRB data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PTPRB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PTPRB expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where PTPRB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	1.000	0.476	.010	31	view →
LUAD	OS	Tertile	All	0.909	1.000	.004	21	view →
HNSC	DFS	Tertile	III,IV	0.405	0.806	.006	11	view →
PDAC	OS	Median	III,IV	0.616	0.993	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PTPRB–CCRCC (DFS)

Open the CCRCC breakdown →