PTPRB

Across TCGA pan-cancer cohorts, PTPRB RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PTPRB’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PTPRB RNA is repressed in tumor relative to normal tissue. In most cancer types PTPRB is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LUAD, KIRP, and KICH are the cancer types where PTPRB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.993	<.001	11	view →
KIRP	Male	All	−2.635	<.001	11	view →
KICH	Male	III,IV	−2.495	<.001	11	view →
LUSC	Female	II,III,IV	−3.561	<.001	9	view →
UCEC	All	All	−1.811	<.001	6	view →
BRCA	All	III,IV	−1.396	<.001	6	view →
HNSC	Female	III,IV	+1.163	<.001	4	view →
THCA	Male	III,IV	−0.945	.017	4	view →
STAD	Male	II,III,IV	+0.721	.004	4	view →
COAD	Female	II,III,IV	−0.515	.008	4	view →
LIHC	All	All	−0.299	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PTPRB–LUAD

Open the LUAD breakdown →