PTPRB

Across TCGA patient cohorts, PTPRB mutation is significantly associated with the RNA expression of many other genes, with 8,123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRB-associated genes across cancer lineages are CHAF1A, RPL36AL, and HSPE1. Each is linked with PTPRB in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRB-to-partner and partner-to-PTPRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1A grouped by PTPRB-low versus PTPRB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRB→partner) and Y-score (partner→PTPRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHAF1A →	+0.567	+2.291	<.001	<.001	3	6
UCEC	RPL36AL →	+0.265	+1.197	.001	.008	3	6
HNSC	HSPE1 →	+0.585	+3.584	.003	.003	3	5
BRCA	SDHA →	+0.442	+3.481	.006	.003	3	5
COAD	ERH →	+0.426	+3.373	.001	.004	3	5
LUAD	UBE2S →	+0.778	+1.830	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,123 associations by consensus.

CHAF1A by PTPRB expression — LUAD

Explore this box plot interactively →