PTPRB

Across TCGA patient cohorts, PTPRB mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRB-associated genes across cancer lineages are C-Raf, Cyclin-B1, and cIAP. Each is linked with PTPRB in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRB-to-partner and partner-to-PTPRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PTPRB-low versus PTPRB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRB→partner) and Y-score (partner→PTPRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.136	+1.882	.026	.031	3	6
UCEC	Cyclin-B1 →	+0.551	+2.459	<.001	<.001	3	5
LUAD	cIAP →	+0.099	+2.334	.008	.003	3	4
COAD	EGFR_pY1068 →	-0.401	-2.576	.003	.011	3	4
STAD	p70-S6K_pT389 →	-0.278	-3.000	.001	.033	3	3
STAD	Cyclin-E2 →	+0.121	+2.606	.033	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

C-Raf by PTPRB expression — COAD

Explore this box plot interactively →