PTPRB

Across TCGA cell cohorts, PTPRB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,181 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PTPRB-associated GO terms across cancer lineages are Regulation of protein maturation, Negative regulation of protein processing, and Regulation of plasminogen activation. Each is linked with PTPRB in more than 10 cancer types. Because this analysis shows association rather than direction, both PTPRB-to-partner and partner-to-PTPRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein maturation grouped by PTPRB-low versus PTPRB-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRB→partner) and Y-score (partner→PTPRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of protein maturation →	+0.123	+2.087	.003	<.001	3	11
SOFT_TISSUE	Negative regulation of protein processing →	+0.181	+1.234	.002	.002	3	11
LIVER	Regulation of plasminogen activation →	+0.311	+1.312	.004	.003	3	10
STOMACH	Positive regulation of protein localization to cell periphery →	+0.100	+1.490	.004	<.001	3	9
KIDNEY	Wound healing →	+0.117	+1.668	.001	.004	3	9
SOFT_TISSUE	Regulation of protein processing →	+0.148	+1.291	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,181 associations by consensus.

Regulation of protein maturation by PTPRB expression — KIDNEY

Explore this box plot interactively →