PTPRB

Across TCGA cell cohorts, PTPRB mutation is significantly associated with the RNA expression of many other genes, with 1,613 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRB-associated genes across cancer lineages are CCNA2, SEPHS1, and KIF23. Each is linked with PTPRB in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRB-to-partner and partner-to-PTPRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNA2 grouped by PTPRB-low versus PTPRB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRB→partner) and Y-score (partner→PTPRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCNA2 →	+0.598	+3.548	.004	.001	3	4
LARGE_INTESTINE	SEPHS1 →	+0.584	+3.584	<.001	<.001	3	4
LUNG_NSCLC_LUAD	KIF23 →	+0.554	+2.621	.002	.003	3	3
LARGE_INTESTINE	TTI2 →	+0.659	+2.949	<.001	<.001	3	3
LARGE_INTESTINE	NOP2 →	+0.516	+3.459	.003	.001	3	3
LARGE_INTESTINE	LANCL1 →	+0.647	+2.265	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,613 associations by consensus.

CCNA2 by PTPRB expression — BLOOD_Leukemia

Explore this box plot interactively →