PTPRA

Across TCGA cell cohorts, PTPRA mutation is significantly associated with the RNA expression of many other genes, with 370 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRA-associated genes across cancer lineages are DCANP1, ART1, and TEX26. Each is linked with PTPRA in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRA-to-partner and partner-to-PTPRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCANP1 grouped by PTPRA-low versus PTPRA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRA→partner) and Y-score (partner→PTPRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCANP1 →	+0.006	+2.125	.001	.004	3	2
LIVER	ART1 →	+0.181	+3.977	<.001	.006	3	1
LIVER	TEX26 →	+0.089	+3.977	.007	.006	3	1
LIVER	C12orf54 →	+0.082	+3.977	<.001	.006	3	1
LIVER	ZPBP2 →	+0.017	+3.977	<.001	.006	3	1
LIVER	ADRB3 →	+0.012	+3.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 370 associations by consensus.

DCANP1 by PTPRA expression — LARGE_INTESTINE

Explore this box plot interactively →