PTPN9

Across TCGA patient cohorts, PTPN9 mutation is significantly associated with the RNA expression of many other genes, with 2,800 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN9-associated genes across cancer lineages are SNORA70D, ZKSCAN7P1, and MIR4777. Each is linked with PTPN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN9-to-partner and partner-to-PTPN9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA70D grouped by PTPN9-low versus PTPN9-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN9→partner) and Y-score (partner→PTPN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SNORA70D →	+0.577	+5.201	<.001	.007	3	2
BLCA	ZKSCAN7P1 →	+0.031	+4.033	<.001	.009	3	2
BLCA	MIR4777 →	+0.275	+2.983	.007	.006	3	2
UCEC	CHEK1 →	+0.641	+2.080	<.001	<.001	3	2
UCEC	DLAT →	+0.480	+1.958	.002	.002	3	2
UCEC	BTBD11 →	-0.715	-3.076	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,800 associations by consensus.

SNORA70D by PTPN9 expression — CESC

Explore this box plot interactively →