PTPN7

Across TCGA cell cohorts, PTPN7 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN7-associated genes across cancer lineages are PRDM7, ST6GAL2, and DEUP1. Each is linked with PTPN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN7-to-partner and partner-to-PTPN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDM7 grouped by PTPN7-low versus PTPN7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN7→partner) and Y-score (partner→PTPN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRDM7 →	+0.133	+3.539	.007	.004	3	1
LARGE_INTESTINE	ST6GAL2 →	+0.824	+3.451	<.001	.005	3	1
LARGE_INTESTINE	DEUP1 →	+0.316	+3.569	<.001	.006	3	1
LARGE_INTESTINE	MAJIN →	+0.098	+4.040	<.001	<.001	3	1
LARGE_INTESTINE	YIPF7 →	+0.076	+3.141	<.001	.002	3	1
LARGE_INTESTINE	OR13D1 →	+0.019	+2.882	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PRDM7 by PTPN7 expression — LARGE_INTESTINE

Explore this box plot interactively →