PTPN5

Across TCGA patient cohorts, PTPN5 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,892 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN5-associated proteins across cancer lineages are HDGFL3, PPP1R12B, and TNXB. Each is linked with PTPN5 in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPN5-to-partner and partner-to-PTPN5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN5 versus HDGFL3 in OV, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN5→partner) and Y-score (partner→PTPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HDGFL3 →	+0.765	+0.407	<.001	.006	3	7
COAD	PPP1R12B →	+0.628	+0.147	.001	.004	3	5
OV	TNXB →	+0.913	+0.488	<.001	<.001	3	5
HNSC	PGM5 →	+0.801	+0.406	<.001	.002	3	5
GBM	PLCB1 →	+0.676	+1.562	<.001	<.001	3	5
BRCA	SYNPO2 →	+0.826	+0.216	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,892 associations by consensus.

PTPN5 vs HDGFL3 — OV

Explore this scatter interactively →