PTPN4

Across TCGA patient cohorts, PTPN4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,012 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PTPN4-associated genes across cancer lineages are FBLN5, SYNPO2, and SRPX. Each is linked with PTPN4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPN4-to-partner and partner-to-PTPN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN4 versus FBLN5 in CCRCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN4→partner) and Y-score (partner→PTPN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FBLN5 →	+1.504	+1.298	<.001	<.001	3	6
CCRCC	SYNPO2 →	+2.461	+2.774	<.001	<.001	3	6
BRCA	SRPX →	+1.480	+0.959	<.001	<.001	3	5
UCEC	MGP →	+1.789	+1.508	<.001	<.001	3	5
CCRCC	DCN →	+2.340	+1.614	<.001	<.001	3	5
CCRCC	AOC3 →	+1.717	+1.803	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,012 associations by consensus.

PTPN4 vs FBLN5 — CCRCC

Explore this scatter interactively →