PTPN3

Across TCGA patient cohorts, PTPN3 mutation is significantly associated with the RNA expression of many other genes, with 4,183 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN3-associated genes across cancer lineages are IGHVII-28-1, CIRBP-AS1, and FBXO7. Each is linked with PTPN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN3-to-partner and partner-to-PTPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVII-28-1 grouped by PTPN3-low versus PTPN3-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN3→partner) and Y-score (partner→PTPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	IGHVII-28-1 →	+0.717	+7.977	<.001	.007	3	3
UCEC	CIRBP-AS1 →	+0.536	+2.410	<.001	<.001	3	3
UCEC	FBXO7 →	+0.364	+1.828	<.001	<.001	3	3
UCEC	LMF2 →	+0.373	+1.628	<.001	<.001	3	3
UCEC	MCM5 →	+0.505	+1.638	<.001	<.001	3	3
UCEC	SAMM50 →	+0.326	+1.954	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,183 associations by consensus.

IGHVII-28-1 by PTPN3 expression — LGG

Explore this box plot interactively →