PTPN3

Across TCGA cell cohorts, PTPN3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTPN3-associated genes across cancer lineages are OR10T2, OR10K2, and OR2C1. Each is linked with PTPN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN3-to-partner and partner-to-PTPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by PTPN3-low versus PTPN3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN3→partner) and Y-score (partner→PTPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10T2 →	+0.595	+4.276	.004	.007	3	2
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	1
LARGE_INTESTINE	OR2C1 →	+0.118	+4.047	<.001	.001	3	1
LARGE_INTESTINE	ELOA3DP →	+0.022	+2.688	<.001	.008	3	1
LARGE_INTESTINE	NCR3 →	+0.110	+2.817	.007	.007	2	2
BLOOD_Lymphoma	CSN1S1 →	+0.067	+3.927	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR10T2 by PTPN3 expression — BLOOD_Leukemia

Explore this box plot interactively →