PTPN23

Across TCGA patient cohorts, PTPN23 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,699 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PTPN23-associated proteins across cancer lineages are MTMR12_S564, NUCKS1_S144, and BCAR1_S694. Each is linked with PTPN23 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPN23-to-partner and partner-to-PTPN23 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN23 versus MTMR12_S564 in LSCC, with a Pearson correlation of -0.26.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN23→partner) and Y-score (partner→PTPN23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MTMR12_S564 →	-0.410	-0.380	.002	.001	3	4
GBM	NUCKS1_S144 →	+0.893	+0.397	<.001	.003	3	4
CCRCC	BCAR1_S694 →	-0.575	-0.456	<.001	<.001	3	4
LUAD	TOP2B_S1524 →	+0.900	+0.472	<.001	<.001	3	4
CCRCC	TECPR2 →	-0.211	-0.340	.003	.004	3	3
LSCC	TMEM94_S1354 →	-0.638	-0.452	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,699 associations by consensus.

PTPN23 vs MTMR12_S564 — LSCC

Explore this scatter interactively →