PTPN23

Across TCGA patient cohorts, PTPN23 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN23-associated genes across cancer lineages are ATM, ERK2, and Chk2_pT68. Each is linked with PTPN23 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPN23-to-partner and partner-to-PTPN23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PTPN23-low versus PTPN23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN23→partner) and Y-score (partner→PTPN23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.400	-2.986	.003	<.001	3	4
UCEC	ERK2 →	+0.134	+1.459	.021	.011	3	3
COAD	Chk2_pT68 →	-0.165	-3.296	.034	.010	3	3
STAD	PDCD4 →	-0.498	-3.000	.030	.036	3	2
STAD	TIGAR →	+0.431	+3.000	.042	.036	3	2
STAD	4E-BP1_pT37_T46 →	-0.701	-3.000	<.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by PTPN23 expression — UCEC

Explore this box plot interactively →