PTPN23

Across TCGA cell cohorts, PTPN23 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,390 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTPN23-associated GO terms across cancer lineages are Endosomal transport, Cytosolic transport, and Regulation of autophagosome maturation. Each is linked with PTPN23 in more than 16 cancer types. Because this analysis shows association rather than direction, both PTPN23-to-partner and partner-to-PTPN23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by PTPN23-low versus PTPN23-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN23→partner) and Y-score (partner→PTPN23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.054	+0.704	<.001	<.001	3	17
STOMACH	Cytosolic transport →	+0.074	+0.769	.003	.004	3	16
SKIN	Regulation of autophagosome maturation →	+0.099	+1.012	<.001	<.001	3	16
LUNG_NSCLC_LUAD	Positive regulation of TORC2 signaling →	+0.109	+0.528	<.001	<.001	3	16
BREAST	Regulation of early endosome to late endosome transport →	+0.149	+0.904	<.001	<.001	3	16
URINARY_TRACT	Positive regulation of early endosome to late endosome transport →	+0.143	+1.045	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,390 associations by consensus.

Endosomal transport by PTPN23 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →