PTPN22

Across TCGA patient cohorts, PTPN22 mutation is significantly associated with the RNA expression of many other genes, with 3,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN22-associated genes across cancer lineages are RN7SKP214, DCST1-AS1, and CELSR3. Each is linked with PTPN22 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN22-to-partner and partner-to-PTPN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP214 grouped by PTPN22-low versus PTPN22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN22→partner) and Y-score (partner→PTPN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP214 →	+0.147	+1.527	<.001	<.001	3	3
UCEC	DCST1-AS1 →	+0.405	+1.761	.003	.004	3	3
UCEC	CELSR3 →	+0.330	+1.415	.006	.002	3	3
HNSC	TRAJ26 →	+0.518	+4.480	.006	.005	3	2
BLCA	OR7E8P →	+0.078	+3.042	<.001	.003	3	2
BLCA	DAZ4 →	+0.010	+3.870	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,148 associations by consensus.

RN7SKP214 by PTPN22 expression — UCEC

Explore this box plot interactively →