PTPN21

Across TCGA patient cohorts, PTPN21 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,191 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PTPN21-associated proteins across cancer lineages are DAPK3, FERMT2, and VCL_S346. Each is linked with PTPN21 in more than 7 cancer types. Because this analysis shows association rather than direction, both PTPN21-to-partner and partner-to-PTPN21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN21 versus DAPK3 in OV, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN21→partner) and Y-score (partner→PTPN21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DAPK3 →	+0.564	+0.983	<.001	<.001	3	8
BRCA	FERMT2 →	+0.651	+0.896	<.001	<.001	3	8
LSCC	VCL_S346 →	+0.584	+0.466	<.001	<.001	3	8
BRCA	PARVA →	+0.487	+0.873	<.001	<.001	3	7
CCRCC	PDLIM7 →	+0.743	+0.609	<.001	<.001	3	7
HNSC	PEAK1 →	+0.255	+0.475	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,191 associations by consensus.

PTPN21 vs DAPK3 — OV

Explore this scatter interactively →