PTPN21

Across TCGA pan-cancer cohorts, PTPN21 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PTPN21’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTPN21 RNA is repressed in tumor relative to normal tissue. In most cancer types PTPN21 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where PTPN21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPN21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.472	<.001	12	view →
KIRC	Male	II,III,IV	−1.035	<.001	12	view →
LUAD	Female	III,IV	−2.409	<.001	11	view →
THCA	All	II,III,IV	−0.968	<.001	9	view →
LUSC	Female	II,III,IV	−2.977	<.001	8	view →
BLCA	Male	All	−1.023	.012	8	view →
UCEC	All	All	−1.455	<.001	6	view →
BRCA	All	III,IV	−1.395	<.001	6	view →
READ	All	All	−1.298	<.001	5	view →
KIRP	Male	All	−0.730	<.001	5	view →
HNSC	Female	III,IV	+0.981	<.001	4	view →
CHOL	Male	All	+1.089	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PTPN21–COAD

Open the COAD breakdown →