PTPN21

Across TCGA patient cohorts, PTPN21 protein abundance is significantly associated with the RNA expression of many other genes, with 9,853 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PTPN21-associated genes across cancer lineages are SEC23A, AGER, and TIMP3. Each is linked with PTPN21 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPN21-to-partner and partner-to-PTPN21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN21 versus SEC23A in BRCA, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN21→partner) and Y-score (partner→PTPN21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEC23A →	+1.043	+0.761	.001	.004	3	4
LUAD	AGER →	+1.087	+0.222	<.001	<.001	3	3
LSCC	TIMP3 →	+1.444	+0.420	<.001	<.001	3	3
LSCC	EHD4 →	+0.477	+0.240	<.001	.002	3	3
BRCA	F13A1 →	+1.417	+0.673	.001	.006	3	3
CCRCC	F2RL3 →	+1.243	+0.320	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,853 associations by consensus.

PTPN21 vs SEC23A — BRCA

Explore this scatter interactively →