PTPN21

Across TCGA patient cohorts, PTPN21 mutation is significantly associated with the RNA expression of many other genes, with 5,095 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN21-associated genes across cancer lineages are PTMAP9, HMGXB4, and SLF1. Each is linked with PTPN21 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPN21-to-partner and partner-to-PTPN21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTMAP9 grouped by PTPN21-low versus PTPN21-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN21→partner) and Y-score (partner→PTPN21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PTMAP9 →	+0.866	+3.321	<.001	.009	3	4
UCEC	HMGXB4 →	+0.376	+1.425	.001	.001	3	4
UCEC	SLF1 →	+0.481	+2.169	<.001	<.001	3	4
UCEC	KIF11 →	+0.615	+1.808	<.001	<.001	3	4
UCEC	EXO1 →	+0.480	+1.901	.003	<.001	3	4
UCEC	CIRBP-AS1 →	+0.584	+1.786	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,095 associations by consensus.

PTMAP9 by PTPN21 expression — STAD

Explore this box plot interactively →