PTPN21

Across TCGA cell cohorts, PTPN21 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,039 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTPN21-associated GO terms across cancer lineages are Regulation of hippo signaling, Endosomal transport, and Vesicle-mediated transport to the plasma membrane. Each is linked with PTPN21 in more than 14 cancer types. Because this analysis shows association rather than direction, both PTPN21-to-partner and partner-to-PTPN21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by PTPN21-low versus PTPN21-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN21→partner) and Y-score (partner→PTPN21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of hippo signaling →	+0.087	+1.479	<.001	<.001	3	15
URINARY_TRACT	Endosomal transport →	+0.055	+1.365	<.001	<.001	3	14
BONE	Vesicle-mediated transport to the plasma membrane →	+0.094	+2.639	<.001	<.001	3	14
OESOPHAGUS	Schwann cell development →	+0.159	+1.206	.003	.001	3	14
OESOPHAGUS	Macroautophagy →	+0.080	+1.325	.005	<.001	3	13
KIDNEY	Regulation of post-translational protein modification →	+0.039	+0.749	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,039 associations by consensus.

Regulation of hippo signaling by PTPN21 expression — STOMACH

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