PTPN21

Across TCGA cell cohorts, PTPN21 mutation is significantly associated with the RNA expression of many other genes, with 843 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN21-associated genes across cancer lineages are GRIFIN, PRAMEF6, and SPATS1. Each is linked with PTPN21 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN21-to-partner and partner-to-PTPN21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIFIN grouped by PTPN21-low versus PTPN21-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN21→partner) and Y-score (partner→PTPN21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GRIFIN →	+0.080	+4.906	<.001	.006	3	2
LUNG_SCLC	PRAMEF6 →	+0.016	+5.029	<.001	.006	3	2
LUNG_SCLC	SPATS1 →	+0.170	+5.029	<.001	.006	3	2
BLOOD_Lymphoma	OR4K1 →	+0.026	+4.247	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	OR52E4 →	+0.089	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	CNGA2 →	+0.066	+5.357	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 843 associations by consensus.

GRIFIN by PTPN21 expression — OESOPHAGUS

Explore this box plot interactively →