PTPN2

Across TCGA patient cohorts, PTPN2 mutation is significantly associated with the RNA expression of many other genes, with 2,434 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN2-associated genes across cancer lineages are UBE2V1P4, RNU6-313P, and HMGB3P23. Each is linked with PTPN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN2-to-partner and partner-to-PTPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2V1P4 grouped by PTPN2-low versus PTPN2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN2→partner) and Y-score (partner→PTPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	UBE2V1P4 →	+0.181	+5.103	<.001	.008	3	3
SKCM	RNU6-313P →	+0.267	+4.075	<.001	.004	3	2
LUAD	HMGB3P23 →	+0.101	+6.912	<.001	<.001	3	2
UCEC	RNU6-939P →	+0.097	+3.075	<.001	.004	3	2
UCEC	RPL22P14 →	+0.061	+1.808	.004	.006	3	2
STAD	MIR4477A →	+0.455	+4.646	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,434 associations by consensus.

UBE2V1P4 by PTPN2 expression — CESC

Explore this box plot interactively →