PTPN13

Across TCGA patient cohorts, PTPN13 mutation is significantly associated with the RNA expression of many other genes, with 7,447 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN13-associated genes across cancer lineages are GHITM, CDK1, and POLE2. Each is linked with PTPN13 in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPN13-to-partner and partner-to-PTPN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHITM grouped by PTPN13-low versus PTPN13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN13→partner) and Y-score (partner→PTPN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GHITM →	+0.491	+1.485	<.001	<.001	3	5
UCEC	CDK1 →	+0.526	+1.379	<.001	<.001	3	5
UCEC	POLE2 →	+0.496	+2.243	<.001	<.001	3	5
COAD	GOT1 →	+0.574	+3.550	<.001	<.001	3	5
UCEC	ZWINT →	+0.722	+1.485	<.001	<.001	3	5
UCEC	PSMC3IP →	+0.648	+1.769	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,447 associations by consensus.

GHITM by PTPN13 expression — UCEC

Explore this box plot interactively →